Nature Communications (Mar 2018)

Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression

  • Leena Latonen,
  • Ebrahim Afyounian,
  • Antti Jylhä,
  • Janika Nättinen,
  • Ulla Aapola,
  • Matti Annala,
  • Kati K. Kivinummi,
  • Teuvo T. L. Tammela,
  • Roger W. Beuerman,
  • Hannu Uusitalo,
  • Matti Nykter,
  • Tapio Visakorpi

DOI
https://doi.org/10.1038/s41467-018-03573-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Understanding of molecular events in cancer requires proteome-level characterisation. Here, proteome profiling of patient samples representing primary and progressed prostate cancer enables the authors to identify pathway alterations that are not reflected at the genomic and transcriptomic levels.