Photothermal-enhanced detoxification metal-organic framework microneedle array for 2-chloroethyl ethyl sulfide-poisoned wound healing

Shuai Guo; Shun Yao; Huanchun Xing; Wenbin Cao; Jianyu Wang; Xinran Zhao; Yajing Wei; Ruizhi Lin; Xin Sui; Yuan Luo; Jun Deng; Jun Yang; Yongan Wang

Materials & Design (Oct 2024)

Photothermal-enhanced detoxification metal-organic framework microneedle array for 2-chloroethyl ethyl sulfide-poisoned wound healing

Shuai Guo,
Shun Yao,
Huanchun Xing,
Wenbin Cao,
Jianyu Wang,
Xinran Zhao,
Yajing Wei,
Ruizhi Lin,
Xin Sui,
Yuan Luo,
Jun Deng,
Jun Yang,
Yongan Wang

Affiliations

Shuai Guo: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; Hebei University of Science and Technology, No. 26 Yuxiang Street, Shijiazhuang, Hebei 050018, China
Shun Yao: State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400038, China
Huanchun Xing: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; Tianjin University of Science and Technology, No.1038 Dagu South Road, Hexi District, Tianjin 300222, China
Wenbin Cao: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
Jianyu Wang: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
Xinran Zhao: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
Yajing Wei: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; Hebei University of Science and Technology, No. 26 Yuxiang Street, Shijiazhuang, Hebei 050018, China
Ruizhi Lin: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
Xin Sui: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
Yuan Luo: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
Jun Deng: State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400038, China; Corresponding authors.
Jun Yang: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; Corresponding authors.
Yongan Wang: State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; Corresponding authors.

Journal volume & issue: Vol. 246
p. 113286

Abstract

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Sulfur mustard (2,2′-dichloroethylsulfide; SM) is a bifunctional alkylating agent that can easily penetrate skin and cause persistent pain and damage. Effective biological dressings are required to treat wounds caused or poisoned by SM. Though the use of SM is regulated under the Chemical Weapons Convention, it is still a threat during wars and terrorist attacks. Herein, we present a photothermal-enhanced detoxification microneedles array (MNA) encapsulated with ZnIn2S4@UiO-66-NH2 (ZnInS/UIO) catalysts for the treatment of 2-chloroethyl ethyl sulfide (CEES, SM analog)-poisoned wounds under simulated sunlight (SSL) irradiation. Due to the excellent photothermal detoxification capability possessed by ZnInS/UIO, the conversion rate of CEES can be significantly increased under SSL exposure. When encased in a polyvinyl alcohol (PVA) MNA and piercing into the skin, ZnInS/UIO catalysts can be released quickly from MNA for detoxification. After applying the resultant ZnInS/UIO-MNA to the CEES-poisoned wound bed, acceleration of the wound healing process and a reduced inflammatory response can be confirmed. In conclusion, ZnInS/UIO-MNA has encouraging potential as a first-aid dressing for CEES-poisoned wound healing in battlefields and injuries related to acts of terrorism.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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