Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling

Abstract

Using the combined of L-arginine with inhibitors of HMG-Co-A reductase simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovannym on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows endotelio- and cardioprotective effects, manifested in preventing the proliferation coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and the normalization of the values of biochemical markers (Total NO, expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy was so effective, that the values obtained in the combination therapy did not differ from those derived from control animals.

Keywords

• эндотелиaльнaя дисфункция
• ингибиторы гмг-ко-а-редyктaзы
• эндотоксин
• l-name
• endothelial dysfunction
• hmg-co-a reductase inhibitor
• sendotoxin
• l-name