Visible-Light-Enhanced Antibacterial Activity of Silver and Copper Co-Doped Titania Formed on Titanium via Chemical and Thermal Treatments

Kanae Suzuki; Misato Iwatsu; Takayuki Mokudai; Maiko Furuya; Kotone Yokota; Hiroyasu Kanetaka; Masaya Shimabukuro; Taishi Yokoi; Masakazu Kawashita

doi:10.3390/molecules28020650

Molecules (Jan 2023)

Visible-Light-Enhanced Antibacterial Activity of Silver and Copper Co-Doped Titania Formed on Titanium via Chemical and Thermal Treatments

Kanae Suzuki,
Misato Iwatsu,
Takayuki Mokudai,
Maiko Furuya,
Kotone Yokota,
Hiroyasu Kanetaka,
Masaya Shimabukuro,
Taishi Yokoi,
Masakazu Kawashita

Affiliations

Kanae Suzuki: Graduate School of Biomedical Engineering, Tohoku University, 6-6-12 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan
Misato Iwatsu: Graduate School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Takayuki Mokudai: Institute of Materials Research, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan
Maiko Furuya: Graduate School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Kotone Yokota: Graduate School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Hiroyasu Kanetaka: Graduate School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Masaya Shimabukuro: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Taishi Yokoi: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Masakazu Kawashita: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

DOI: https://doi.org/10.3390/molecules28020650
Journal volume & issue: Vol. 28, no. 2
p. 650

Abstract

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Dental implants made of titanium (Ti) are used in dentistry, but peri-implantitis is a serious associated problem. Antibacterial and osteoconductive Ti dental implants may decrease the risk of peri-implantitis. In this study, titania (TiO2) co-doped with silver (Ag) at 2.5 at.% and copper (Cu) at 4.9 at.% was formed on Ti substrates via chemical and thermal treatments. The Ag and Cu co-doped TiO2 formed apatite in a simulated body fluid, which suggests osteoconductivity. It also showed antibacterial activity against Escherichia coli, which was enhanced by visible-light irradiation. This enhancement might be caused by the synergistic effect of the release of Ag and Cu and the generation of •OH from the sample. Dental implants with such a Ag and Cu co-doped TiO2 formed on their surface may reduce the risk of peri-implantitis.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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