Nature Communications (Jan 2020)

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

  • Agian Jeffilano Barinda,
  • Koji Ikeda,
  • Dhite Bayu Nugroho,
  • Donytra Arby Wardhana,
  • Naoto Sasaki,
  • Sakiko Honda,
  • Ryota Urata,
  • Satoaki Matoba,
  • Ken-ichi Hirata,
  • Noriaki Emoto

DOI
https://doi.org/10.1038/s41467-020-14387-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Vascular senescence is closely associated with individual ageing, while its causative role remains unclear. Here Barinda et al. generate endothelial cell-specific progeroind mice, and reveal that endothelial cell senescence directly induces metabolic disorders through senescence-messaging secretomes.