Perbandingan Obat Kumur Benzydamine Hydrochloride 22,5 mg dan Ketamin 40 mg dalam Mengurangi Nyeri Tenggorok dan Suara Serak Akibat Intubasi Endotrakeal

Abstract

Sore throat and hoarseness is a frequent complication in general anesthesia with endotracheal intubation, which affects the comfort and satisfaction of patients after surgery. This study aimed to determine the effectiveness of ketamine and benzydamine hydrochloride mouthwash in reducing sore throat and hoarseness following general anesthesia with endotracheal intubation. Fifty eight patients aged 16–60 years undergoing general anesthesia at the Central Operating Theater of H. Adam Malik General Hospital Medan with endotracheal intubation during October–November 2013 were double-blind randomized and divided equally into 2 groups. Ten minutes before entering the operating room, patients received ketamine or benzydamine hydrochloride mouthwash as much as 15 mL for a 60 seconds gargle. After surgery, patients were given ketorolac. Assessment on sore throat and hoarseness was performed at 1, 6, 12, 24 after the completion of surgery. Six patients were excluded from the study. The incidence of sore throat in the first hour in ketamine group was 14 of 26 and 18 of 26 in hydrochloride benzydamine group. Meanwhile, the incidence of hoarseness in the first hour for both groups were 16 of 26 and 18 of 26, respectively. In general, benzydamine hydrochloride is better than ketamine although the difference is not statistically significant.

Keywords

• Benzydamine hydrochloride
• endotracheal intubation
• ketamine
• sore throat
• hoarseness