Subcortical serotonin 5HT2c receptor-containing neurons sex-specifically regulate binge-like alcohol consumption, social, and arousal behaviors in mice

Abstract

The neurobiological mechanisms by which binge alcohol consumption disrupts social and emotional functioning are unknown. Here, the authors demonstrate that sex-specific social and arousal disturbances induced by binge alcohol consumption are driven by dysregulation of serotonergic signaling and activation of 5HT2c receptor-containing neurons in the lateral habenula in mice.