Application of mini-pigs as a model for developing new methods of ischemic heart disease (IHD) treatment
V. N. Tikhonov,
P. M. Larionov,
A. V. Tikhonov
Affiliations
V. N. Tikhonov
RAMS Russian Federation SB RAMS Institution of the Russian Academy of Sciences Institute of Cytology and Genetics Novosibirsk
P. M. Larionov
Ministry of health of the Russian Federation Russian Federation Institution of the Ministry of Health of the Russian Federation Institute of Circulatory Pathology. E. N. Meshalkin Institute of Circulatory Pathology Novosibirsk
A. V. Tikhonov
RAMS Russian Federation SB RAMS Russian Academy of Medical Sciences Research Institute of Therapy Novosibirsk
At the last 30 years the application of the new laboratory species mini-pigs is progressively increasing in medical and biological research of atherosclerosis and other disorders of cardiovascular system. Mini-pigs differ from traditional experimental animals in maximal similarity of their anatomy and physiological functions of cardiovascular, digestive, excretory, and nervous systems with human ones. In the Institute of Cytology and Genetics SB RAS the specialized laboratory mini- and micro-pigs adapted for using under our conditions were created. In 2010 several hundreds of studies on mini-pigs were conducted in Russian Federation and abroad. The present review highlights some experimental works that could be applied for wide use in medicine.
