Nature Communications (Jun 2018)

Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling

  • Jiangtao Li,
  • Manman Kong,
  • Baokun Qiao,
  • Richmond Lee,
  • Xiaowei Zhao,
  • Zhiyong Jiang

DOI
https://doi.org/10.1038/s41467-018-04885-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Enantioselective substitution reactions of racemic alkyl halides are inherently limited by the specificity of their stereochemical course (SN1 or SN2). Here, the authors report a radical coupling strategy for the enantioselective aminoalkylation of α-bromoketones for modular, highly enantioselective Csp3−Csp3 bond formation.