Nature Communications (Jan 2018)

Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

  • Tie-Yuan Zhang,
  • Christopher L. Keown,
  • Xianglan Wen,
  • Junhao Li,
  • Dulcie A. Vousden,
  • Christoph Anacker,
  • Urvashi Bhattacharyya,
  • Richard Ryan,
  • Josie Diorio,
  • Nicholas O’Toole,
  • Jason P. Lerch,
  • Eran A. Mukamel,
  • Michael J. Meaney

DOI
https://doi.org/10.1038/s41467-017-02748-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Environmental enrichment has functional and molecular effects on mammalian hippocampus. Here, Zhang and colleagues show that environmental enrichment of mice is correlated with dorsal-ventral asymmetry in transcription and DNA methylation of the dentate gyrus.