CHIMIA (May 2003)

Peptide Receptors – From Selective Molecular Recognition Towards Catalytic Activity

  • Helma Wennemers

DOI
https://doi.org/10.2533/000942903777679352
Journal volume & issue
Vol. 57, no. 5

Abstract

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The development of diketopiperazine receptors, a class of two-armed receptors that bind peptides with high selectivity, has been achieved by a combination of on-bead combinatorial binding assays and conformational analysis using X-ray crystal structure analysis and NMR spectroscopy. Furthermore, a general method for the discovery of catalysts within split-and-mix libraries has been developed that is based on the co-immobilization of the potential catalyst and one reactant on the same bead.

Keywords