Non-Coding RNA (Dec 2023)

Genetic Loss of miR-205 Causes Increased Mammary Gland Development

  • Alessandra Cataldo,
  • Douglas G. Cheung,
  • John P. Hagan,
  • Matteo Fassan,
  • Sukhinder Sandhu-Deol,
  • Carlo M. Croce,
  • Gianpiero Di Leva,
  • Marilena V. Iorio

DOI
https://doi.org/10.3390/ncrna10010004
Journal volume & issue
Vol. 10, no. 1
p. 4

Abstract

Read online

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.

Keywords