Nature Communications (Feb 2016)

A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

  • Han Sun,
  • Liqun Luo,
  • Bachchu Lal,
  • Xinrong Ma,
  • Lieping Chen,
  • Christine L. Hann,
  • Amy M. Fulton,
  • Daniel J. Leahy,
  • John Laterra,
  • Min Li

DOI
https://doi.org/10.1038/ncomms10339
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

The potassium channel KCNK9 mediates important biological processes and is often overexpressed in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against the extracellular domain of KCNK9 and show that it inhibits cancer growth and metastasis in vivothrough both cell autonomous and immune-dependent cellular cytotoxicity.