Features of the perimenopausal period in women, depending on the body weight at birth

Abstract

Features of the perimenopausal period in women,  depending on the body weight at birth A.B. Khuraseva Kursk State Medical University, Russian Federation Currently, the problem of the timely diagnosis, optimization of management and prevention of long-term complications of perimenopausal disorders is very important. Body weight at birth, being a hereditary characteristic, determines not only the phenotypic features, but also the features of the formation, flowering and extinction of the female reproductive system. The aim of the study was to reveal the relationship between birth weight and the perimenopausal period, to improve the dispensary observation of women born with polar body weight. Patients and Methods: a retrospective and prospective examination of 952 women was carried out. Depending on the weight at birth, the patients were divided into three groups: group 1 uncluded 312 women born with a body weight of 2000–2800 g; group 2 uncluded 276 patients with a body weight of 3200–3600 g at birth; group 3 included 364 patients with a body weight at birth from 4000–4800 g. The features of the perimenopausal period, with evaluation of neurovegetative, psychoemotional and metabolic symptoms were studied. Results: the lowest mean age of the onset of premenopause was in the 1st group — 44.7±0.7 years, in the 2nd grouр — 47.7±0.6 years, in the third — 49.8±0.4 years, respectively. The early onset of menopause was in 37.5% of women in the 1st group; the perimenopausal period was characterized by early appearance of symptoms and a severe course of neurovegetative and urological disorders. The initial manifestation of genitourinary menopausal syndrome (GUMS) in the first group was more often manifested by trophic disorders in 61.5±2.8%. Urologic symptoms of the GUMS dominated in the first group 69.2±2.6%, and appeared earlier than in other compared groups. There was a decrease in sexual activity in the 1st group (73.1±2.5%). Conclusion: women born with a small body weight (2000–2800) are in the risk group for the early onset of menopause, and are more likely to suffer from neurovegetative disorders and manifestations of genitourinary menopausal syndrome in the perimenopause period. In contrast to the vasomotor manifestations of climacteric syndrome, which, as a rule, decrease with time, genitourineral menopausal syndrome, steadily progressing, adversely affects the quality of life and sexual health of women, and practically cannot be relieved without treatment. This explains the need to use timely therapy in the risk group, in women who had a low birth weight. Key words: perimenopausal period, menopause, genitourineral menopausal syndrome, birth weight, climacteric syndrome. For citation: A.B. Khuraseva. Features of the perimenopausal period in women, depending on the body weight at birth. Russian journal of Woman and Child Health. 2018;1(1):40–43.