Scientific Reports (May 2023)

Efficacy of closed cell self expandable metallic stent for peripheral arterial disease in the porcine iliac artery

  • Dae Sung Ryu,
  • Dong-Sung Won,
  • Ji Won Kim,
  • Yubeen Park,
  • Song Hee Kim,
  • Jeon Min Kang,
  • Chu Hui Zeng,
  • Dohyung Lim,
  • Hyun Choi,
  • Jung-Hoon Park

DOI
https://doi.org/10.1038/s41598-023-35878-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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Abstract This study aimed to investigate the efficacy of a closed-cell self-expandable metallic stent (SEMS) with or without expanded-polytetrafluoroethylene (e-PTFE)-covering membrane in a porcine iliac artery model. Twelve Yorkshire domestic pigs were divided into a bare closed-cell SEMS (B-SEMS) group (n = 6) and covered closed-cell SEMS (C-SEMS) group (n = 6). Both closed-cell SEMSs were placed in the right or left iliac artery. Thrombogenicity score in the C-SEMS group was significantly higher than that in the B-SEMS group (p = 0.004) after 4 weeks. Angiographic findings of mean luminal diameters at 4 weeks follow-up did not differ significantly between B-SEMS and C-SEMS groups. Neointimal hyperplasia thickness as well as degree of inflammatory cell infiltration and collagen deposition in the C-SEMS group was significantly greater than that in the B-SEMS group (p < 0.001). Closed-cell SEMSs successfully maintained patency for 4 weeks without stent-related complications in the porcine iliac artery. Although mild thrombus with neointimal hyperplasia was observed in the C-SEMS group, subsequent occlusion, and in-stent stenosis did not occur in any of the pigs until the end of the study. Closed-cell SEMS with or without the e-PTFE covering membrane is effective and safe for the porcine iliac artery.