Vascular mechanotransduction data in a rodent model of diabetes: Pressure-induced regulation of SHP2 and associated signaling in the rat inferior vena cava
Kevin M. Rice,
Nandini D.P.K. Manne,
Ravikumar Arvapalli,
Gautam K. Ginjupalli,
Eric R. Blough
Affiliations
Kevin M. Rice
Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA; Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; Biotechnology Graduate Program West Virginia State University, Institute, WV, USA; Department of Health and Human Service, School of Kinesiology, Marshall University, Huntington, WV, USA; Correspondence to: Center for Diagnostic Nanosystems, Robert C. Byrd Biotechnology Science Center, Marshall University, Room 241D 1700 3rd Ave., Huntington, WV 25755-1090, USA. Fax: +1 304-696-3766.
Nandini D.P.K. Manne
Department of Public Heath, Marshall University, Huntington, WV, USA
Ravikumar Arvapalli
Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA
Gautam K. Ginjupalli
Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA
Eric R. Blough
Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA; Biotechnology Graduate Program West Virginia State University, Institute, WV, USA; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA
The effect of diabetes on vascular mechano-transductive response is of great concern. Given the higher rate of vein graft failures associated with diabetes, understanding the multiple cellular and molecular events associated with vascular remodeling is of vital importance. This article represents data related to a study published in Cardiovascular Diabetology [1] (Rice et al., 2006) and Open Journal of Endocrine and Metabolic Diseases [2] (Rice et al., 2015) evaluating the effect of pressurization on rat inferior venae cavae (IVC). Provided within this articles is information related to the method and processing of raw data related to our prior publish work and Data in Brief articles [3,4] (Rice et al., 2017), as well as the evaluation of alternation in SHP-2 signaling and associated proteins in response to mechanical force. IVC from lean and obese animals were exposed to a 30 min perfusion of 120 mm Hg pressure and evaluated for changes in expression of SHP2, BCL-3, BCL-XL, HSP 27, HSP 70, and PI3K p85, along with the phosphorylation of SHP-2 (Tyr 542).
