Microbiological Profiles of Dental Implants in Metabolic Syndrome Patients: A Case-Control Study
Bianca Di Murro,
Marta Moretti,
Enrico De Smaele,
Claudio Letizia,
Carla Lubrano,
Pier Carmine Passarelli,
Antonio D’Addona,
Giorgio Pompa,
Piero Papi
Affiliations
Bianca Di Murro
Department of Oral and Maxillo-Facial Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Marta Moretti
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
Enrico De Smaele
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
Claudio Letizia
Unit of Secondary Arterial Hypertension, Department of Translational and Precision Medicine, “Sapienza” University of Rome, 00161 Rome, Italy
Carla Lubrano
Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
Pier Carmine Passarelli
Oral Surgery and Implantology Unit, Department of Head and Neck, Institute of Clinical Dentistry, Catholic University of Sacred Hearth, Fondazione Policlinico Universitario Gemelli, 00168 Rome, Italy
Antonio D’Addona
Oral Surgery and Implantology Unit, Department of Head and Neck, Institute of Clinical Dentistry, Catholic University of Sacred Hearth, Fondazione Policlinico Universitario Gemelli, 00168 Rome, Italy
Giorgio Pompa
Department of Oral and Maxillo-Facial Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
Piero Papi
Department of Oral and Maxillo-Facial Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
There is a lack of knowledge on the possible influence of systemic conditions on peri-implantitis. The aim of this case-control study is to evaluate the difference in terms of oral pathogens’ concentrations in the peri-implant sulcus of a group of patients affected by metabolic syndrome (Mets) compared to healthy subjects. For each patient, peri-implant sulcular biofilm samples were obtained by inserting two sterile endodontic paper points in the deepest aspect of the peri-implant sulcus for 30 s. The quantitative real-time polymerase chain reaction was performed to evaluate total bacterial counts of six pathogens. Patients were screened for peri-implant diseases and clinical and radiographic parameters were recorded. A total of 50 patients was enrolled in the study, 25 affected by Mets and 25 healthy. Significantly higher bacterial counts were discovered for Aggregatibacter actinomycetemcomitans (p = 0.0008), Prevotella intermedia (p = 0.0477) and Staphylococcus aureus (p = 0.034) in MetS patients compared to healthy subjects. Performing a sub-group analysis, considering peri-implant status and dividing patients by MetS diagnosis, no statistically significant (p < 0.05) differences were found. For the first time, a correlation between MetS presence and a greater prevalence of some bacterial species in the peri-implant sulcus was reported, irrespectively from peri-implant status (health vs. disease).
