Bioassay-Guided Isolation of New Flavonoid Glycosides from <i>Platanus</i> × <i>acerifolia</i> Leaves and Their <i>Staphylococcus aureus</i> Inhibitory Effects
Xiying Wu,
Yu Tang,
Ezzat E. A. Osman,
Jiang Wan,
Wei Jiang,
Guoxun Yang,
Juan Xiong,
Quangang Zhu,
Jin-Feng Hu
Affiliations
Xiying Wu
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
Yu Tang
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Ezzat E. A. Osman
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
Jiang Wan
Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Taizhou 318000, China
Wei Jiang
School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China
Guoxun Yang
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
Juan Xiong
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
Quangang Zhu
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China
Jin-Feng Hu
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
Despite the rapid advances in drug R&D, there is still a huge need for antibacterial medications, specifically for the methicillin-resistant Staphylococcus aureus (MRSA). Inspired by the research where a viable class of MRSA inhibitors was found in the species Platanus occidentalis, a S. aureus inhibition screening-guided phytochemical reinvestigation on Platanus × acerifolia (London plane tree) leaves were performed with four flavonoid glycosides garnered, including two new compounds, quercetin-3-O-α-l-(2″-E-p-coumaroyl-3″-Z-p-coumaroyl)-rhamnopyranoside (E,Z-3′-hydroxyplatanoside, 1) and quercetin-3-O-α-l-(2″-Z-p-coumaroyl-3″-E-p-coumaroyl)-rhamnopyranoside (Z,E-3′-hydroxyplatanoside, 2). All of the isolates showed significant S. aureus ATCC 25904 inhibitory activity with MICs ranging from 4 to 64 μg/mL, suggesting the potential of discovering drug leads for the control of S. aureus from such a rich, urban landscaping plant in the Platanus genus.
