An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(<i>1H</i>)-Ones

Abstract

We have efficiently synthesized mono as well as bis and spiro cyclic products of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by refluxing a reaction mixture of the three components in deep eutectic solvent (DES) to generating “libraries from libraries”. Synthesized Spiro fused heterotricyclic compounds containing urea moiety are potent against bacteria. Overall, in the antibacterial study, from the synthesized compounds, some of the 3,4–dihydropyrimidin-2-(1H)-one compounds were found to possess anti-bacterial efficacy.

Keywords

• 3,4-dihydropyrimidin-2(<i>1H</i>)-ones
• bis-dihydropyrimidinones
• spirofused heterotricyclic
• deep eutectic solvent and antibacterial activity