Survival of patients with hepatocellular carcinoma treated with immunotherapy experience of a third level center.

Abstract

Introduction and Objectives: Hepatocellular carcinoma (HCC) ranks sixth among tumors, the third cause of death worldwide and accounts for 85-90% of primary liver tumors. Recently, the use of immunotherapy as first-line treatment offers a survival of 18 months. The objective of this study is to assess the survival and adverse effects of the different immune checkpoint inhibitor therapies in our population Materials and Patients: Patients who received immunotherapy at the Central Military Hospital from January 2021 to April 2023 were included. The following were recorded: leukocytes, hemoglobin, platelets, PT, INR, BT, AST, ALT, ALP, albumin, MELD, MELD-Na, ALBI, MELD 3.0 before and after treatment, calculation of survival, progression-free time and adverse effects Results: 18 patients with stage A were included 2 patients, BCLC B 6 patients and BCLC C 10 patients, age 67.72 ± 14.40 years, 11 (61%) men, the following immunotherapy schemes were given: atezolizumab + bevacizumab 13 patients and 5 patients with Nivolumab. The following variables were compared before and after immunotherapy: leukocytes, hemoglobin, platelets, PT, INR, BT, AST, ALT, ALP, albumin, MELD, MELD-Na, ALBI, MELD 3.0. Without finding statistical differences (Table 1). Adverse effects were 1 patient presented with clostridiode and 2 with immune-mediated hepatitis without improvement after treatment, which required suspension of immunotherapy and initiation of second line treatment. Overall survival was 19 months and progression-free time 15 months. Conclusions: The overall survival of the patients was 19 months, the adverse effects that the patients appeared were similar to those reported in the literature.