Nature Communications (Feb 2019)

Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp3–H bond oxidative functionalization of acetonitrile

  • Tian-Jun He,
  • Zongren Ye,
  • Zhuofeng Ke,
  • Jing-Mei Huang

DOI
https://doi.org/10.1038/s41467-019-08762-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Direct α-functionalization of acetonitrile, a bulk chemical, is usually limited to its enolate chemistry. Here, the authors show an electro-oxidative C(sp3)–H bond functionalization of acetonitrile with thiols to afford tetrasubstituted olefins with high stereoselectivity.