Epidemiologia e Serviços de Saúde (Dec 2023)

Clinical-epidemiological characteristics and survival of cases of severe acute respiratory syndrome (SARS) due to COVID-19, according to the COVID-19 vaccination schedule in Brazil, 2021-2022: a prospective study

  • Carlos Martins Neto,
  • Victor Nogueira da Cruz Silveira,
  • Fábio Nogueira da Silva,
  • José de Jesus Dias Júnior,
  • Maria dos Remédios Freitas Carvalho Branco,
  • Alcione Miranda dos Santos,
  • Bruno Luciano Carneiro Alves de Oliveira

DOI
https://doi.org/10.1590/s2237-96222023000400003.en
Journal volume & issue
Vol. 32, no. 4

Abstract

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ABSTRACT Objective To analyze the clinical and sociodemographic characteristics and survival of individuals with severe acute respiratory syndrome due to COVID-19 according to the COVID-19 vaccination schedule, Brazil, 2021-2022. Methods This was a cohort study based on data from the Influenza Epidemiological Surveillance Information System; the Kaplan-Meier and Survival Tree methods were used to analyze survival. Results Among the 559,866 hospitalized cases, a higher proportion of vaccinated individuals was found among female (15.0%), elderly people aged ≥ 80 (34.5%), people from the Southeast region (15.7%), those who did not undergo respiratory support (21.2%) and those who did progress to death (15.2%); the survival curve showed that risk of death for unvaccinated individuals was higher in all age groups (p-value < 0.001); elderly people aged ≥ 80, who did not undergo mechanical ventilation and who had a booster dose had lower risk when compared to their peers who had two doses or were unvaccinated (hazard ratio = 0.64; 95%CI 0.62;0.67). Conclusion Lowest risk of death was found in vaccinated individuals, especially those who had two doses or a booster dose as well.

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