PECULIARITY OF CYTOKINE SECRETION IN PREGNANT WOMEN WITH CHRONIC DISSEMINATED INTRAVASCULAR COAGULATION

Abstract

Abstract. The cytokine concentration measured in serum and brush cytology of cervical canal in pregnant women with chronic disseminated intravascular syndrome. The serum concentrations of inflammatory cytokines were significantly elevated in brush cytology of cervical canal in pregnant women with chronic disseminated intravascular syndrome, especially in patients with infection genesis recurrent pregnancy loss in anamnesis. The profiles of Th1-cytokines in serum and brush cytology of cervical canal in pregnancy women were different depending on activity of chronic disseminated intravascular syndrome. The analysis of opposition cytokines pools reveals an similarity of TNFα/IL-10 in serum and brush cytology of cervical canal, IFNγ/IL-4 и IL-1RA/ IL-1β in brush cytology of cervical canal were significantly reduced in pregnant women with chronic disseminated intravascular syndrome.

Keywords

• cytokines
• chronic disseminated intravascular syndrome
• cervical canal