PLoS Neglected Tropical Diseases (Jan 2016)

Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series.

  • Miguel M Cabada,
  • Martha Lopez,
  • Maria Cruz,
  • Jennifer R Delgado,
  • Virginia Hill,
  • A Clinton White

DOI
https://doi.org/10.1371/journal.pntd.0004361
Journal volume & issue
Vol. 10, no. 1
p. e0004361

Abstract

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Triclabendazole is reported to be highly effective in treatment of human fascioliasis. We present 7 of 19 selected cases of human fascioliasis referred to our center in the Cusco region of Peru that failed to respond to triclabendazole. These were mostly symptomatic adults of both sexes that continued passing Fasciola eggs in the stool despite multiple treatments with 2 doses of triclabendazole at 10 mg/kg per dose. We documented the presence of eggs by rapid sedimentation and Kato Katz tests after each treatment course. We found that repeated triclabendazole courses were not effective against fascioliasis in this group of people. These findings suggest that resistance to triclabendazole may be an emerging problem in the Andes.