Multimodal neuroimaging with optically pumped magnetometers: A simultaneous MEG-EEG-fNIRS acquisition system
Xingyu Ru,
Kaiyan He,
Bingjiang Lyu,
Dongxu Li,
Wei Xu,
Wenyu Gu,
Xiao Ma,
Jiayi Liu,
Congcong Li,
Tingyue Li,
Fufu Zheng,
Xiaozhou Yan,
Yugang Yin,
Hongfeng Duan,
Shuai Na,
Shuangai Wan,
Jie Qin,
Jingwei Sheng,
Jia-Hong Gao
Affiliations
Xingyu Ru
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Kaiyan He
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Bingjiang Lyu
Changping Laboratory, Beijing, China
Dongxu Li
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Wei Xu
Changping Laboratory, Beijing, China
Wenyu Gu
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Xiao Ma
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Jiayi Liu
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Congcong Li
Changping Laboratory, Beijing, China
Tingyue Li
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Fufu Zheng
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China
Xiaozhou Yan
Beijing PsycheArk Science & Technology Development Co., Ltd., Beijing, China
Yugang Yin
Beijing PsycheArk Science & Technology Development Co., Ltd., Beijing, China
Hongfeng Duan
Beijing PsycheArk Science & Technology Development Co., Ltd., Beijing, China
Shuai Na
National Biomedical Imaging Center, Peking University, Beijing, China
Shuangai Wan
Beijing Automation Control Equipment Institute, Beijing, China
Jie Qin
Beijing Automation Control Equipment Institute, Beijing, China
Jingwei Sheng
Beijing Quanmag Healthcare, Beijing, China
Jia-Hong Gao
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China; Changping Laboratory, Beijing, China; National Biomedical Imaging Center, Peking University, Beijing, China; McGovern Institute for Brain Research, Peking University, Beijing, China; Center for MRI Research, Academy for Advance Interdisciplinary Studies, Peking University, Beijing 100871, China; Corresponding author.
Multimodal neuroimaging plays an important role in neuroscience research. Integrated noninvasive neuroimaging modalities, such as magnetoencephalography (MEG), electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), allow neural activity and related physiological processes in the brain to be precisely and comprehensively depicted, providing an effective and advanced platform to study brain function. Noncryogenic optically pumped magnetometer (OPM) MEG has high signal power due to its on-scalp sensor layout and enables more flexible configurations than traditional commercial superconducting MEG. Here, we integrate OPM-MEG with EEG and fNIRS to develop a multimodal neuroimaging system that can simultaneously measure brain electrophysiology and hemodynamics. We conducted a series of experiments to demonstrate the feasibility and robustness of our MEG-EEG-fNIRS acquisition system. The complementary neural and physiological signals simultaneously collected by our multimodal imaging system provide opportunities for a wide range of potential applications in neurovascular coupling, wearable neuroimaging, hyperscanning and brain-computer interfaces.
