USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway

Yuhui Zhou; Yunxia Zhao; Wei Ma; Lin Zhang; Yuanzhu Jiang; Wei Dong

doi:10.1007/s12672-022-00600-3

Discover Oncology (Dec 2022)

USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway

Yuhui Zhou,
Yunxia Zhao,
Wei Ma,
Lin Zhang,
Yuanzhu Jiang,
Wei Dong

Affiliations

Yuhui Zhou: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University
Yunxia Zhao: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University
Wei Ma: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University
Lin Zhang: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University
Yuanzhu Jiang: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University
Wei Dong: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University

DOI: https://doi.org/10.1007/s12672-022-00600-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Highlights 1. CHCHD4 was highly expressed in LUAD. 2. Knockdown of CHCHD4 suppressed the malignant phenotype of LUAD. 3. USF1 upregulated CHCHD4 and promoted LUAD progression. 4. Knockdown of CHCHD4 inhibited LUAD progression.

Published in Discover Oncology

ISSN: 2730-6011 (Online)
Publisher: Springer
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.springer.com/journal/12672/

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Abstract

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