Cognitive complaint inversely associated to UHR transition

Abstract

The aim of this study was to identify the impact of staging on a six-months transition in Ultra-High Risk (UHR) youth.Subjects were enrolled at assessment; evolution was monitored for six months. Clinical determinants (unusual thought content, perceptual abnormalities, cognitive complaint, etc.) were collected.37 non-psychotic and 39 UHR subjects were included. 13 UHR (35.2 %) experienced psychotic transition, while none of non-psychotic subjects did log-rank p < 0.001. Self-reported cognitive complaint was inversely associated to transition OR 0.13 95 % IC [0.03–0.64]. Unusual Thought Content was associated to psychotic transition 0R 8.57 95 % IC [1.17–63]. Self-reported cognitive complaint could be a protective transition marker in UHR.

Keywords

• Ultra-high risk
• Psychotic transition
• Cognitive complaint
• Self-assessment
• Early intervention