Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
Chen Yijie,
Sha Wenqi,
Zhang Yifan,
Kou Wanyi,
Yang Liu,
Guo Ruixin,
Li Chenyang,
Zhao Junjie,
Wang Zhenghui
Affiliations
Chen Yijie
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Sha Wenqi
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Zhang Yifan
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Kou Wanyi
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Yang Liu
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Guo Ruixin
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Li Chenyang
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Zhao Junjie
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Wang Zhenghui
Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, No.157 Xi Wu Road, Xi’anShaanxi, 710004, People’s Republic of China
Dysregulation of chondrogenic differentiation is associated with osteoarthritis (OA). The myokine irisin is beneficial in OA treatment; yet, the underlying mechanism is not fully understood. Long noncoding RNAs (lncRNAs) act as important regulators of chondrocyte differentiation. This study was conducted to address the role of lncRNAs in mediating irisin-induced chondrocyte differentiation.
