Nature Communications (May 2022)
Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
- Amos C. Lee,
- Yongju Lee,
- Ahyoun Choi,
- Han-Byoel Lee,
- Kyoungseob Shin,
- Hyunho Lee,
- Ji Young Kim,
- Han Suk Ryu,
- Hoe Suk Kim,
- Seung Yeon Ryu,
- Sangeun Lee,
- Jong-Ho Cheun,
- Duck Kyun Yoo,
- Sumin Lee,
- Hansol Choi,
- Taehoon Ryu,
- Huiran Yeom,
- Namphil Kim,
- Jinsung Noh,
- Yonghee Lee,
- Inyoung Kim,
- Sangwook Bae,
- Jinhyun Kim,
- Wooseok Lee,
- Okju Kim,
- Yushin Jung,
- Changhoe Kim,
- Seo Woo Song,
- Yeongjae Choi,
- Junho Chung,
- Byung Gee Kim,
- Wonshik Han,
- Sunghoon Kwon
Affiliations
- Amos C. Lee
- Bio-MAX Institute, Seoul National University
- Yongju Lee
- Department of Electrical and Computer Engineering, Seoul National University
- Ahyoun Choi
- Interdisciplinary Program in Bioengineering, Seoul National University
- Han-Byoel Lee
- Department of Surgery, Seoul National University College of Medicine
- Kyoungseob Shin
- Department of Electrical and Computer Engineering, Seoul National University
- Hyunho Lee
- Department of Electrical and Computer Engineering, Seoul National University
- Ji Young Kim
- Biomedical Research Institute, Seoul National University Hospital
- Han Suk Ryu
- Cancer Research Institute, Seoul National University
- Hoe Suk Kim
- Biomedical Research Institute, Seoul National University Hospital
- Seung Yeon Ryu
- Biomedical Research Institute, Seoul National University Hospital
- Sangeun Lee
- Biomedical Research Institute, Seoul National University Hospital
- Jong-Ho Cheun
- Department of Surgery, Seoul National University College of Medicine
- Duck Kyun Yoo
- Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine
- Sumin Lee
- Department of Electrical and Computer Engineering, Seoul National University
- Hansol Choi
- Department of Electrical and Computer Engineering, Seoul National University
- Taehoon Ryu
- ATG LIfetech Inc
- Huiran Yeom
- Bio-MAX Institute, Seoul National University
- Namphil Kim
- Department of Electrical and Computer Engineering, Seoul National University
- Jinsung Noh
- Department of Electrical and Computer Engineering, Seoul National University
- Yonghee Lee
- Department of Electrical and Computer Engineering, Seoul National University
- Inyoung Kim
- Artificial Intelligence Institute, Seoul National University
- Sangwook Bae
- Bio-MAX Institute, Seoul National University
- Jinhyun Kim
- Department of Electrical and Computer Engineering, Seoul National University
- Wooseok Lee
- Department of Electrical and Computer Engineering, Seoul National University
- Okju Kim
- ATG LIfetech Inc
- Yushin Jung
- ATG LIfetech Inc
- Changhoe Kim
- Celemics, Inc
- Seo Woo Song
- Bio-MAX Institute, Seoul National University
- Yeongjae Choi
- School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST)
- Junho Chung
- Cancer Research Institute, Seoul National University
- Byung Gee Kim
- Bio-MAX Institute, Seoul National University
- Wonshik Han
- Department of Surgery, Seoul National University College of Medicine
- Sunghoon Kwon
- Bio-MAX Institute, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-022-30299-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
The spatial context of epitranscriptomic features in the tumour microenvironment remains poorly understood. Here, a method for transcriptomic and epitranscriptomic analysis of immunofluorescence-stained tissue, Select-seq, is applied to stem cell-like microniches in triple negative breast cancer.
