Nature Communications (Nov 2021)

The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model

  • Eldin Jašarević,
  • Elizabeth M. Hill,
  • Patrick J. Kane,
  • Lindsay Rutt,
  • Trevonn Gyles,
  • Lillian Folts,
  • Kylie D. Rock,
  • Christopher D. Howard,
  • Kathleen E. Morrison,
  • Jacques Ravel,
  • Tracy L. Bale

DOI
https://doi.org/10.1038/s41467-021-26634-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Exposure at birth to maternal microbiota has significant effects on offspring health and development. Here, the authors validate a model where inoculation of mice at birth with human vaginal microbiota produces significant effects on offspring health that are further amplified by an unhealthy prenatal environment.