Boletín Médico del Hospital Infantil de México (May 2017)

MALDI imaging: beyond classic diagnosis

  • Laura Denise Manzanares-Meza,
  • Claudia Ivonne Gutiérrez-Román,
  • Oscar Medina-Contreras

DOI
https://doi.org/10.1016/j.bmhimx.2017.03.004
Journal volume & issue
Vol. 74, no. 3
pp. 212 – 218

Abstract

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Mass spectrometry has been the focus of technology development and application for imaging for several decades. Imaging mass spectrometry using matrix-assisted laser desorption ionization is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.

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