Nature Communications (May 2017)
YAP regulates cell mechanics by controlling focal adhesion assembly
- Giorgia Nardone,
- Jorge Oliver-De La Cruz,
- Jan Vrbsky,
- Cecilia Martini,
- Jan Pribyl,
- Petr Skládal,
- Martin Pešl,
- Guido Caluori,
- Stefania Pagliari,
- Fabiana Martino,
- Zuzana Maceckova,
- Marian Hajduch,
- Andres Sanz-Garcia,
- Nicola Maria Pugno,
- Gorazd Bernard Stokin,
- Giancarlo Forte
Affiliations
- Giorgia Nardone
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Jorge Oliver-De La Cruz
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Jan Vrbsky
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Cecilia Martini
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Jan Pribyl
- CEITEC MU, Masaryk University
- Petr Skládal
- CEITEC MU, Masaryk University
- Martin Pešl
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Guido Caluori
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Stefania Pagliari
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Fabiana Martino
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Zuzana Maceckova
- Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc
- Marian Hajduch
- Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc
- Andres Sanz-Garcia
- Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki
- Nicola Maria Pugno
- Department of Civil, Laboratory of Bio-inspired and Graphene Nanomechanics, Environmental and Mechanical Engineering, University of Trento
- Gorazd Bernard Stokin
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- Giancarlo Forte
- International Clinical Research Center (ICRC), St Anne’s University Hospital
- DOI
- https://doi.org/10.1038/ncomms15321
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The transcriptional co-activator YAP is known to operate downstream of mechanical signals arising from the cell niche. Here the authors demonstrate that YAP controls cell mechanics, force development and adhesion strength by promoting the transcription of genes related to focal adhesions.
