Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Sara Lombardi; Gabriella Honeth; Christophe Ginestier; Ireneusz Shinomiya; Rebecca Marlow; Bharath Buchupalli; Patrycja Gazinska; John Brown; Steven Catchpole; Suling Liu; Ariel Barkan; Max Wicha; Anand Purushotham; Joy Burchell; Sarah Pinder; Gabriela Dontu

doi:10.1016/j.stemcr.2014.05.005

Stem Cell Reports (Jun 2014)

Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Sara Lombardi,
Gabriella Honeth,
Christophe Ginestier,
Ireneusz Shinomiya,
Rebecca Marlow,
Bharath Buchupalli,
Patrycja Gazinska,
John Brown,
Steven Catchpole,
Suling Liu,
Ariel Barkan,
Max Wicha,
Anand Purushotham,
Joy Burchell,
Sarah Pinder,
Gabriela Dontu

Affiliations

Sara Lombardi: Research Oncology, King’s College London, London SE1 9RT, UK
Gabriella Honeth: Research Oncology, King’s College London, London SE1 9RT, UK
Christophe Ginestier: Centre de Recherche et Cancérologie, Marseille, Inserm, CRCM, U1068, France
Ireneusz Shinomiya: Research Oncology, King’s College London, London SE1 9RT, UK
Rebecca Marlow: Research Oncology, King’s College London, London SE1 9RT, UK
Bharath Buchupalli: Research Oncology, King’s College London, London SE1 9RT, UK
Patrycja Gazinska: Research Oncology, King’s College London, London SE1 9RT, UK
John Brown: Research Oncology, King’s College London, London SE1 9RT, UK
Steven Catchpole: Research Oncology, King’s College London, London SE1 9RT, UK
Suling Liu: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Ariel Barkan: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Max Wicha: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Anand Purushotham: Research Oncology, King’s College London, London SE1 9RT, UK
Joy Burchell: Research Oncology, King’s College London, London SE1 9RT, UK
Sarah Pinder: Research Oncology, King’s College London, London SE1 9RT, UK
Gabriela Dontu: Research Oncology, King’s College London, London SE1 9RT, UK

DOI: https://doi.org/10.1016/j.stemcr.2014.05.005
Journal volume & issue: Vol. 2, no. 6
pp. 780 – 793

Abstract

Read online

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

Published in Stem Cell Reports

ISSN: 2213-6711 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: http://www.cell.com/stem-cell-reports/home

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