Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

Marta Reyman; Marlies A. van Houten; Rebecca L. Watson; Mei Ling J. N. Chu; Kayleigh Arp; Wouter J. de Waal; Irene Schiering; Frans B. Plötz; Rob J. L. Willems; Willem van Schaik; Elisabeth A. M. Sanders; Debby Bogaert

doi:10.1038/s41467-022-28525-z

Nature Communications (Feb 2022)

Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

Marta Reyman,
Marlies A. van Houten,
Rebecca L. Watson,
Mei Ling J. N. Chu,
Kayleigh Arp,
Wouter J. de Waal,
Irene Schiering,
Frans B. Plötz,
Rob J. L. Willems,
Willem van Schaik,
Elisabeth A. M. Sanders,
Debby Bogaert

Affiliations

Marta Reyman: Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital and University Medical Center Utrecht
Marlies A. van Houten: Department of Pediatrics, Spaarne Gasthuis
Rebecca L. Watson: Medical Research Council and University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh
Mei Ling J. N. Chu: Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital and University Medical Center Utrecht
Kayleigh Arp: Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital and University Medical Center Utrecht
Wouter J. de Waal: Department of Pediatrics, Diakonessenhuis
Irene Schiering: Department of Pediatrics, Spaarne Gasthuis
Frans B. Plötz: Department of Pediatrics, Tergooiziekenhuis
Rob J. L. Willems: Department of Medical Microbiology, University Medical Centre Utrecht
Willem van Schaik: Institute of Microbiology and Infection, University of Birmingham
Elisabeth A. M. Sanders: Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital and University Medical Center Utrecht
Debby Bogaert: Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital and University Medical Center Utrecht

DOI: https://doi.org/10.1038/s41467-022-28525-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Here, in a randomized trial of 147 infants receiving distinct antibiotic regimens for early-onset neonatal sepsis, Reyman et al. characterize the gut microbiome and resistance profiles, finding differential effects of antibiotic combinations on microbial community composition and antimicrobial resistance genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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