Nature Communications (Nov 2022)
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation
- Joshua I. Warrick,
- Wenhuo Hu,
- Hironobu Yamashita,
- Vonn Walter,
- Lauren Shuman,
- Jenna M. Craig,
- Lan L. Gellert,
- Mauro A. A. Castro,
- A. Gordon Robertson,
- Fengshen Kuo,
- Irina Ostrovnaya,
- Judy Sarungbam,
- Ying-bei Chen,
- Anuradha Gopalan,
- Sahussapont J. Sirintrapun,
- Samson W. Fine,
- Satish K. Tickoo,
- Kwanghee Kim,
- Jasmine Thomas,
- Nagar Karan,
- Sizhi Paul Gao,
- Timothy N. Clinton,
- Andrew T. Lenis,
- Timothy A. Chan,
- Zhiyu Chen,
- Manisha Rao,
- Travis J. Hollman,
- Yanyun Li,
- Nicholas D. Socci,
- Shweta Chavan,
- Agnes Viale,
- Neeman Mohibullah,
- Bernard H. Bochner,
- Eugene J. Pietzak,
- Min Yuen Teo,
- Gopa Iyer,
- Jonathan E. Rosenberg,
- Dean F. Bajorin,
- Matthew Kaag,
- Suzanne B. Merrill,
- Monika Joshi,
- Rosalyn Adam,
- John A. Taylor,
- Peter E. Clark,
- Jay D. Raman,
- Victor E. Reuter,
- Yu Chen,
- Samuel A. Funt,
- David B. Solit,
- David J. DeGraff,
- Hikmat A. Al-Ahmadie
Affiliations
- Joshua I. Warrick
- Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine
- Wenhuo Hu
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Hironobu Yamashita
- Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine
- Vonn Walter
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Lauren Shuman
- Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine
- Jenna M. Craig
- Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine
- Lan L. Gellert
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Mauro A. A. Castro
- Bioinformatics and Systems Biology Laboratory, Federal University of Parana
- A. Gordon Robertson
- BC Cancer, Canada’s Michael Smith Genome Sciences Centre
- Fengshen Kuo
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Irina Ostrovnaya
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Judy Sarungbam
- Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Ying-bei Chen
- Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Anuradha Gopalan
- Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Sahussapont J. Sirintrapun
- Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Samson W. Fine
- Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Satish K. Tickoo
- Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Kwanghee Kim
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Jasmine Thomas
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Nagar Karan
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Sizhi Paul Gao
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Timothy N. Clinton
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Andrew T. Lenis
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Timothy A. Chan
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Zhiyu Chen
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Manisha Rao
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Travis J. Hollman
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Yanyun Li
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Nicholas D. Socci
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Shweta Chavan
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Agnes Viale
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Neeman Mohibullah
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Bernard H. Bochner
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Eugene J. Pietzak
- Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Min Yuen Teo
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Gopa Iyer
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Jonathan E. Rosenberg
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Dean F. Bajorin
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Matthew Kaag
- Department of Urology, Pennsylvania State University College of Medicine
- Suzanne B. Merrill
- Department of Urology, Pennsylvania State University College of Medicine
- Monika Joshi
- Department of Medicine, Division of Hematology-Oncology, Penn State Cancer Institute
- Rosalyn Adam
- Department of Urology, Boston Children’s Hospital
- John A. Taylor
- Department of Urology, University of Kansas Medical Center
- Peter E. Clark
- Levine Cancer Institute, Atrium Health
- Jay D. Raman
- Department of Urology, Pennsylvania State University College of Medicine
- Victor E. Reuter
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Yu Chen
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Samuel A. Funt
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- David B. Solit
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- David J. DeGraff
- Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine
- Hikmat A. Al-Ahmadie
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-34251-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Bladder cancer can often exhibit genomic and morphological heterogeneity. Here, the authors use genomics analysis to show lineage plasticity of bladder cancers with squamous differentiation, and identify key transcription factors related to this morphological and immune heterogeneity.
