Novel Copper(II) Complexes with <i>N</i><sup>4</sup>,<i>S</i>-Diallylisothiosemicarbazones as Potential Antibacterial/Anticancer Drugs
Vasilii Graur,
Irina Usataia,
Ianina Graur,
Olga Garbuz,
Paulina Bourosh,
Victor Kravtsov,
Carolina Lozan-Tirsu,
Greta Balan,
Valeriu Fala,
Aurelian Gulea
Affiliations
Vasilii Graur
Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD-2009 Chisinau, Moldova
Irina Usataia
Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD-2009 Chisinau, Moldova
Ianina Graur
Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD-2009 Chisinau, Moldova
Olga Garbuz
Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD-2009 Chisinau, Moldova
Paulina Bourosh
Institute of Applied Physics, Moldova State University, 5 Academiei Street, MD-2028 Chisinau, Moldova
Victor Kravtsov
Institute of Applied Physics, Moldova State University, 5 Academiei Street, MD-2028 Chisinau, Moldova
Carolina Lozan-Tirsu
Department of Preventive Medicine, State University of Medicine and Pharmacy “Nicolae Testemitanu”, 165 Stefan cel Mare si Sfant Bd., MD-2004 Chisinau, Moldova
Greta Balan
Department of Preventive Medicine, State University of Medicine and Pharmacy “Nicolae Testemitanu”, 165 Stefan cel Mare si Sfant Bd., MD-2004 Chisinau, Moldova
Valeriu Fala
Department of Preventive Medicine, State University of Medicine and Pharmacy “Nicolae Testemitanu”, 165 Stefan cel Mare si Sfant Bd., MD-2004 Chisinau, Moldova
Aurelian Gulea
Laboratory of Advanced Materials in Biofarmaceutics and Technics, Moldova State University, 60 Mateevici Street, MD-2009 Chisinau, Moldova
The six new copper(II) coordination compounds [Cu(HL1)Cl2] (1), [Cu(HL1)Br2] (2), [Cu(H2O)(L1)(CH3COO)]·1.75H2O (3), [Cu(HL2)Cl2] (4), [Cu(HL2)Br2] (5), [Cu(H2O)(L2)(CH3COO)] (6) were synthesized with 2-formyl- and 2-acetylpyridine N4,S-diallylisothiosemicarbazones (HL1 and HL2). The new isothiosemicarbazones were characterized by NMR, FTIR spectroscopy, and X-ray crystallography ([H2L2]I). All copper(II) coordination compounds were characterized by elemental analysis, FTIR spectroscopy, and molar conductivity of their 1mM methanol solutions. Furthermore, the crystal structure of complex 3 was determined using single-crystal X-ray diffraction analysis. The studied complexes manifest antibacterial and antifungal activities, that in many cases are close to the activity of medical drugs used in this area, and in some cases even exceed them. The complexes 4 and 5 showed the highest indexes of selectivity (280 and 154) and high antiproliferative activity against BxPC-3 cell lines that surpass the activity of Doxorubicin. The complexes 1–3 also manifest antioxidant activities against cation radicals ABTS•+ that are close to that of trolox, the antioxidant agent used in medicine.
