The characterization of CD8+ T-cell responses in COVID-19

Yuanting Yang; Heather Miller; Maria G. Byazrova; Fabio Cndotti; Kamel Benlagha; Niels Olsen Saraiva Camara; Junming Shi; Huamei Forsman; Pamela Lee; Lu Yang; Alexander Filatov; Zhimin Zhai; Chaohong Liu

doi:10.1080/22221751.2023.2287118

Emerging Microbes and Infections (Dec 2024)

The characterization of CD8+ T-cell responses in COVID-19

Yuanting Yang,
Heather Miller,
Maria G. Byazrova,
Fabio Cndotti,
Kamel Benlagha,
Niels Olsen Saraiva Camara,
Junming Shi,
Huamei Forsman,
Pamela Lee,
Lu Yang,
Alexander Filatov,
Zhimin Zhai,
Chaohong Liu

Affiliations

Yuanting Yang: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Heather Miller: Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, USA
Maria G. Byazrova: Laboratory of Immunochemistry, National Research Center Institute of Immunology, Federal Medical Biological Agency of Russia, Moscow, Russia
Fabio Cndotti: Division of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Kamel Benlagha: Institut de Recherche Saint-Louis, Université de Paris, Paris, France
Niels Olsen Saraiva Camara: Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil
Junming Shi: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Huamei Forsman: Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Pamela Lee: Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
Lu Yang: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Alexander Filatov: Laboratory of Immunochemistry, National Research Center Institute of Immunology, Federal Medical Biological Agency of Russia, Moscow, Russia
Zhimin Zhai: Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China
Chaohong Liu: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China

DOI: https://doi.org/10.1080/22221751.2023.2287118
Journal volume & issue: Vol. 13, no. 1

Abstract

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ABSTRACTThis review gives an overview of the protective role of CD8+ T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by CD8+ T cells in unexposed cohorts are described. Additionally, the relevance of resident CD8+ T cells in the upper and lower airway during infection and CD8+ T-cell responses following vaccination are discussed, including recent worrisome breakthrough infections and variants of concerns (VOCs). Lastly, we explain the correlation between CD8+ T cells and COVID-19 severity. This review aids in a deeper comprehension of the association between CD8+ T cells and SARS-CoV-2 and broadens a vision for future exploration.

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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