Nature Communications (Jan 2023)
Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness
- Ronald Allan M. Panganiban,
- Zhiping Yang,
- Maoyun Sun,
- Chan Young Park,
- David I. Kasahara,
- Niccole Schaible,
- Ramaswamy Krishnan,
- Alvin T. Kho,
- Elliot Israel,
- Marc B. Hershenson,
- Scott T. Weiss,
- Blanca E. Himes,
- Jeffrey J. Fredberg,
- Kelan G. Tantisira,
- Stephanie A. Shore,
- Quan Lu
Affiliations
- Ronald Allan M. Panganiban
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Zhiping Yang
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Maoyun Sun
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Chan Young Park
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- David I. Kasahara
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Niccole Schaible
- Emergency Medicine, Beth Israel Deaconess Medical Center
- Ramaswamy Krishnan
- Emergency Medicine, Beth Israel Deaconess Medical Center
- Alvin T. Kho
- Computational Health informatics Program, Boston Children’s Hospital
- Elliot Israel
- Asthma Research Center, Brigham and Women’s Hospital, Harvard Medical School
- Marc B. Hershenson
- Department of Pediatrics and Department of Molecular and Integrative Physiology, University of Michigan Medical School
- Scott T. Weiss
- Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Blanca E. Himes
- Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania
- Jeffrey J. Fredberg
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Kelan G. Tantisira
- Division of Pediatric Respiratory Medicine, University of California San Diego and Rady Children’s Hospital
- Stephanie A. Shore
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Quan Lu
- Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health
- DOI
- https://doi.org/10.1038/s41467-022-35739-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway hyperresponsiveness in mice.
