Nature Communications (Nov 2020)
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
- Jing Zhao,
- Yuan Fu,
- Yu Yamazaki,
- Yingxue Ren,
- Mary D. Davis,
- Chia-Chen Liu,
- Wenyan Lu,
- Xue Wang,
- Kai Chen,
- Yesesri Cherukuri,
- Lin Jia,
- Yuka A. Martens,
- Lucy Job,
- Francis Shue,
- Thanh Thanh Nguyen,
- Steven G. Younkin,
- Neill R. Graff-Radford,
- Zbigniew K. Wszolek,
- David A. Brafman,
- Yan W. Asmann,
- Nilüfer Ertekin-Taner,
- Takahisa Kanekiyo,
- Guojun Bu
Affiliations
- Jing Zhao
- Department of Neuroscience, Mayo Clinic
- Yuan Fu
- Department of Neuroscience, Mayo Clinic
- Yu Yamazaki
- Department of Neuroscience, Mayo Clinic
- Yingxue Ren
- Department of Health Sciences Research, Mayo Clinic
- Mary D. Davis
- Department of Neuroscience, Mayo Clinic
- Chia-Chen Liu
- Department of Neuroscience, Mayo Clinic
- Wenyan Lu
- Department of Neuroscience, Mayo Clinic
- Xue Wang
- Department of Health Sciences Research, Mayo Clinic
- Kai Chen
- Department of Neuroscience, Mayo Clinic
- Yesesri Cherukuri
- Department of Health Sciences Research, Mayo Clinic
- Lin Jia
- Department of Neuroscience, Mayo Clinic
- Yuka A. Martens
- Department of Neuroscience, Mayo Clinic
- Lucy Job
- Department of Neuroscience, Mayo Clinic
- Francis Shue
- Department of Neuroscience, Mayo Clinic
- Thanh Thanh Nguyen
- Department of Neuroscience, Mayo Clinic
- Steven G. Younkin
- Department of Neuroscience, Mayo Clinic
- Neill R. Graff-Radford
- Department of Neurology, Mayo Clinic
- Zbigniew K. Wszolek
- Department of Neurology, Mayo Clinic
- David A. Brafman
- School of Biological and Health Systems Engineering, Arizona State University
- Yan W. Asmann
- Department of Health Sciences Research, Mayo Clinic
- Nilüfer Ertekin-Taner
- Department of Neuroscience, Mayo Clinic
- Takahisa Kanekiyo
- Department of Neuroscience, Mayo Clinic
- Guojun Bu
- Department of Neuroscience, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-020-19264-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phenotype.
