Recent advances in β-cyclodextrin-based catalyst systems for the synthesis of heterocyclic compounds via multicomponent reactions (MCRs)

Abstract

Cyclodextrins (CDs) are essential compounds because of their wide applications in many fields. They are cyclic oligosaccharides with lipophilic internal cavities and hydrophilic external surfaces that link the α-D-glucopyranose portion. β-Cyclodextrin (β-CD) is a non-toxicity, cheap, green, and renewability macrocycle with excellent performance in organic transformation. β-CD is a green catalyst with satisfactory catalytic activity in diverse organic changes. Regarding green chemistry’s goals, β-CD opens the way to effective catalysts for various reactions. Heterocyclic compounds are among the most prominent organic compounds in numerous organic materials, pharmaceuticals, and natural products. Heterocyclic compounds are essential in pharmaceutical products and show different biological activities in multiple illnesses. Thus, there is a tendency to develop novel, green, and helpful syntheses of heterocyclic systems, which has been a big challenge in synthetic organic chemistry. Using β-CD as catalysts for synthesizing heterocyclic compounds makes the procedure milder, easier, and less toxic, making it an eco-friendly substitute compared to the reported approaches. This review underlines the applications of β-CD-based catalysts for synthesizing heterocyclic compounds covering 2019–2023. This study will be helpful to researchers in the investigation areas of organic synthesis, medicinal chemistry, synthetic materials, and pharmacological medicine..

Keywords

• β-Cyclodextrin (β-CD)
• Heterocyclic compounds
• Multicomponent reactions
• Supramolecular catalysis
• One-pot