Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Aidan McGowan; Julie Y. An; Sally Tanakchi; Mahir Maruf; Akhil Muthigi; Arvin George; Daniel Su; Maria J. Merino; W. Marston Linehan; Shawna L. Boyle; Adam R. Metwalli

doi:10.1016/j.eucr.2017.03.017

Urology Case Reports (Jul 2017)

Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Aidan McGowan,
Julie Y. An,
Sally Tanakchi,
Mahir Maruf,
Akhil Muthigi,
Arvin George,
Daniel Su,
Maria J. Merino,
W. Marston Linehan,
Shawna L. Boyle,
Adam R. Metwalli

Affiliations

Aidan McGowan: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Julie Y. An: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Sally Tanakchi: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Mahir Maruf: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Akhil Muthigi: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Arvin George: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Daniel Su: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Maria J. Merino: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
W. Marston Linehan: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Shawna L. Boyle: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA
Adam R. Metwalli: National Cancer Institute, National Institutes of Health, Urologic Oncology Branch, Bethesda, MD, USA

DOI: https://doi.org/10.1016/j.eucr.2017.03.017
Journal volume & issue: Vol. 13, no. C
pp. 107 – 109

Abstract

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Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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