Crystal structure of 2-fluoro-N-(1,3-thiazol-2-yl)benzamide

Abstract

In the title compound, C10H7FN2OS, the mean plane of the central amide fragment (r.m.s. deviation = 0.048 Å) makes dihedral angles of 35.28 (8) and 10.14 (12)° with those of the fluorobenzene and thiazole rings, respectively. The thiazole S and amide O atoms lie to the same side of the molecule. In the crystal, pairs of N—H...N hydrogen bonds connect the molecules into inversion dimers with R22(8) motifs, and weak C—H...O interactions connect the molecules into C(6) [001] chains. Together, the N—H...N and C—H...O hydrogen bonds generate (100) sheets.

Keywords

• crystal structure
• thiazole derivatives
• cancer cell-growth inhibitors
• carboxamides
• 1,3-thiazole
• benzamide
• hydrogen bonding