Angiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report

Abstract

Next-generation sequencing (NGS) is an emerging method with the potential of pan-pathogen screening. This study described a case of eosinophilic meningitis (EoM) with enzyme-linked immunosorbent assay (ELISA)-negative results for Angiostrongylus cantonensis (A. cantonensis), Trichinella spiralis and Paragonimus westermani and a positive identification of A. cantonensis by NGS in the cerebrospinal fluid.

Keywords

• Eosinophilic meningitis
• Cerebrospinal fluid
• Next-generation sequencing