Pleiotropic ACE inhibitor effects: any benefits for sulfhydryl agents?

Abstract

Clinical pharmacology of ACE inhibitors is described, comparing pharmacological effects of agents with or without sulfhydryl groups in their molecules. Sulfhydryl group-containing ACE inhibitors – captopril and especially zofenopril – are characterized by greater antioxidant properties and, potentially, stronger cardio- and vasoprotective action. Literature data confirm benefits of these sulfhydryl ACE inhibitors as first-line medications for treating acute myocardial infarction, other coronary heart disease forms, arterial hypertension and diabetes mellitus, due to important pathogenetic role of oxidative stress.

Keywords

• ace inhibitor
• captopril
• zofenopril