Клиническая практика (Sep 2017)

THE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS

  • T V Stavenchuk,
  • E D Kosmachova,
  • I A Shelestova,
  • A A Slavinsky,
  • E A Terman,
  • A A Verevkin,
  • L A Medvedeva,
  • K O Barbuhatty,
  • Z G Tatarintseva,
  • V A Porchanov

DOI
https://doi.org/10.17816/clinpract8328-33
Journal volume & issue
Vol. 8, no. 3
pp. 28 – 33

Abstract

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The following article describes tactics of recipient management when a rejection episode of a heart transplant is being suspected. We have discovered some new figures to assess biopsy samples through computerised morphometric study, which can both improve and clarify biopsy results. CD3+ (T-cells) and CD 68+ (macrophages) figures make it possible to determine the extent of transplant rejection in accordance with the International Society for Heart and Lung Transplantation diagnostic criteria (sensitivity 91%, specificity 91%).

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