Nature Communications (Apr 2016)

CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

  • Tilman Schneider-Hohendorf,
  • Hema Mohan,
  • Christian G. Bien,
  • Johanna Breuer,
  • Albert Becker,
  • Dennis Görlich,
  • Tanja Kuhlmann,
  • Guido Widman,
  • Sebastian Herich,
  • Christiane Elpers,
  • Nico Melzer,
  • Klaus Dornmair,
  • Gerhard Kurlemann,
  • Heinz Wiendl,
  • Nicholas Schwab

DOI
https://doi.org/10.1038/ncomms11153
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Rasmussen Encephalitis is a rare neurological disease accompanied by inflammation and T cell infiltration in the brain. Here the authors show that the severity of this disease correlates with clonal CD8 T cell expansion.