Iodophor-/H<sub>2</sub>O<sub>2</sub>-Mediated 2-Sulfonylation of Indoles and <i>N</i>-Methylpyrrole in Aqueous Phase
Yashuai Liu,
Yutong Yuan,
Jing He,
Sheng Han,
Yan Liu
Affiliations
Yashuai Liu
Basic Sciences Department, Shanxi Agricultural University, Jinzhong 030800, China
Yutong Yuan
The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832004, China
Jing He
The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832004, China
Sheng Han
The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832004, China
Yan Liu
The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832004, China
A convenient and efficient strategy for the preparation of 2-sulfonylindoles has been achieved through iodophor-/H2O2-mediated 2-sulfonylation of indoles with readily available sulfonyl hydrazides in the aqueous phase. Iodophor is commercially available and serves as the green catalyst and aqueous phase. A series of 2-sulfonylated products from indoles and N-methylpyrrole were synthesized in moderate yields in only 10 min. Control experiments were also conducted to reveal the mechanism of action. This method is environment friendly, easy to operate and suitable for a wide range of substrates.
