Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study

Abstract

<ul> <li><strong>BACKGROUND</strong>: Sleep bruxism is a common sleep disorder with unclear etiology and no definitive treatment. Recent</li> <li>suggested medications are not often practically used due to their numerous limitations. Based on the fact that sleep bruxism occurs most often in the second stage of non-REM sleep, this study aimed to assess the effect of trazodone on sleep bruxism.<strong> <br /> </strong></li> <li><strong>METHODS</strong>: This pilot study was conducted as a before-after design on 28 children and adolescents with 6-18 years of age suffering from sleep bruxism referring by children and adolescents mental health clinic, children dental specialists and pediatricians. The treatment started with 0.5mg/kg/day. In non-responders, it was weekly added by 0.5 mg/kg/day (with optimum of 2 mg/kg/day). Frequency of bruxism and related morning face/jaw pain were assessed daily from two weeks before (baseline) to four weeks after starting the intervention by the parents/roommate.</li> <li><strong>RESULTS</strong>: Findings showed a significant reduction in the frequency of both bruxism and related morning pain from baseline to the 2nd and the 4th weeks of the intervention (P&lt;0.001). Minor side effects such as drowsiness, nausea and dry mouth were seen among approximately one-third of the patients. These side effects were self-limited and tolerable.</li> <li><strong>CONCLUSIONS: </strong>Trazodone could be effective in reducing the frequency of sleep bruxism and its related morning face/jaw pain. Well-designed placebo-controlled trials are needed to confirm the results.</li> <li><strong>KEY WORDS</strong>: Sleep bruxism, trazodone, teeth clenching, teeth grinding.</li> </ul>

Keywords

• Sleep bruxism, trazodone, teeth clenching, teeth grinding.