Stereotypic wheel running decreases cortical activity in mice

Simon P. Fisher; Nanyi Cui; Laura E. McKillop; Jessica Gemignani; David M. Bannerman; Peter L. Oliver; Stuart N. Peirson; Vladyslav V. Vyazovskiy

doi:10.1038/ncomms13138

Nature Communications (Oct 2016)

Stereotypic wheel running decreases cortical activity in mice

Simon P. Fisher,
Nanyi Cui,
Laura E. McKillop,
Jessica Gemignani,
David M. Bannerman,
Peter L. Oliver,
Stuart N. Peirson,
Vladyslav V. Vyazovskiy

Affiliations

Simon P. Fisher: Department of Physiology, Anatomy and Genetics, University of Oxford
Nanyi Cui: Department of Physiology, Anatomy and Genetics, University of Oxford
Laura E. McKillop: Department of Physiology, Anatomy and Genetics, University of Oxford
Jessica Gemignani: European Space Agency, Advanced Concepts Team
David M. Bannerman: Department of Experimental Psychology, University of Oxford
Peter L. Oliver: Department of Physiology, Anatomy and Genetics, University of Oxford
Stuart N. Peirson: Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute, University of Oxford
Vladyslav V. Vyazovskiy: Department of Physiology, Anatomy and Genetics, University of Oxford

DOI: https://doi.org/10.1038/ncomms13138
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Sleep need is thought to accumulate gradually over waking periods and is associated with changes in neuronal activity. Here the authors show that in mice cortical firing rates increase between the beginning and end of wakefulness periods but this increase is not seen in waking periods with voluntary stereotypic wheel running.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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