Leucine regulates autophagy via acetylation of the mTORC1 component raptor

Sung Min Son; So Jung Park; Eleanna Stamatakou; Mariella Vicinanza; Fiona M. Menzies; David C. Rubinsztein

doi:10.1038/s41467-020-16886-2

Nature Communications (Jun 2020)

Leucine regulates autophagy via acetylation of the mTORC1 component raptor

Sung Min Son,
So Jung Park,
Eleanna Stamatakou,
Mariella Vicinanza,
Fiona M. Menzies,
David C. Rubinsztein

Affiliations

Sung Min Son: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
So Jung Park: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Eleanna Stamatakou: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Mariella Vicinanza: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
Fiona M. Menzies: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge
David C. Rubinsztein: Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge

DOI: https://doi.org/10.1038/s41467-020-16886-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Leucine is a critical amino acid that inhibits autophagy. Here, the authors show that the leucine inhibits autophagy in most cell types, predominantly via its catabolite acetyl CoA, which drives acetylation of raptor, which activates mTORC1, a negative regulator of this catabolic process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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